Lopinavir – a double edged sword for both HIV and HPV?

By February 20, 2014Pharma Beat

Currently, there are no effective medical treatments for human papillomavirus (HPV) infection, which is the leading cause of cervical cancers. However, recent findings from a small study in Manchester suggest a treatment may be right under our noses – lopinavir (Kaletra), a protease inhibitor used to treat HIV.

Lopinavir, given twice daily for two weeks, was applied to the cervix of 40 Kenyan women who had high-grade, borderline or low-grade pre-cancerous cervical disease resulting from HPV infection. Remarkably, after 3 months, 19 of the 23 women who began the study with high-grade disease had returned to normal and two were classified as having low-grade disease. Results were similar for women with low grade disease.

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