A paper published last week by Gatti and colleagues in the Annals of Allergy Asthma & Immunology (2011;107:202–6), reviewed the evidence supporting the clinical link between allergic and bone diseases. While long-term corticosteroid use appears to have a negative effect on bone metabolism, other drugs used in allergic diseases appear to improve bone health. Leukotriene modifiers (LTMs) appear to improve fracture healing and antihistamines may have a positive effect on bone mass. Other interesting examples include NSAIDS, which appear to negatively affect the fracture healing process, and Vitamin D, which has been found to play key roles in both immune regulation and bone health. The animal models and observational studies conducted to date support a close link between the immune and skeletal systems – giving rise to a new discipline called osteoimmunology.